@rosepoptosis @jeffgilchrist Do you understand how Remdesivir and Monulpiravir work? What do they also target? Baric developed BOTH.. https://t.co/7rujQFOpxc https://t.co/8jlcwDmDKK
@TheDrJon @WWFFD11 @frank_zelenko @janiesaysyay Baric created RDV. RDV inhibits RdRP, but it's IV only.. Too late to inhibit viral loading. Zinc + HCQ can be given EARLY to block RdRP and block viral loading. But Baric couldn't patent it. https://t.c
@RonJCarson1 Remdesivir is an RdRP inhibitor, which means it HAS TO BE USED EARLY, not after Viral load has peaked and cytokine response commences. And, of course, it seems to have some nasty kidney and liver side effects. Zinc + Ionophores for me, thank
@Harvard2H Dan, you and I both know Baric is no dummy. He wouldn't have put his name on that paper unless it was "golden". He knew disrupting RdRP was the key, but trick was to use it EARLY. But He/Fauci wanted a drug he could patent @$3000/treatment.
@Kempton @Muller_Lab Yes! Nice chembio work in that paper to complement Gordon et al’s biochem work on the RDV triphosphate mechanism. https://t.co/VAeHtWbMJA
@drbeen_medical
@PowerDNS_Bert Hey Bert-good q. Active triphosphate of 524 and RDV (GS-443902) has remarkable specificity for SARS-2 RdRp (Km ~9 nM). Incorporation by viral RdRp ➡️ delayed chain termination at the i+3 position. Good refs: https://t.co/ZDKDBlZHAv https://t
RT @UMBCPhageHunter: OK, not much response to my questions about a coronavirus paper for teaching. How about I start with a seed I am consi…
OK, not much response to my questions about a coronavirus paper for teaching. How about I start with a seed I am considering for Genetics Lab? Might be a little tough, but interesting. Maybe also its prequal (ref. 17). https://t.co/k4ZYl8RiHq
RT @UAlberta_MMI: And more: Calvin et al. Part 2. Inhibition of SARS-CoV-2 RNA Pol with remdesivir. https://t.co/KiHymyfQzE
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. https://t.co/KitC1TJGQl
Remdesivir links God's light-activated Creation of the "Calvin Cycle" to biophysically constrained viral latency across kingdoms. https://t.co/GJ5WAk6tT2 /3
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency https://t.co/503JPitzuB
En esa misma línea, el Journal Of Biological Chemistry proporcionó un estudio de laboratorio que mostraba la acción directa que tenía el remdesivir para INHIBIR (ojo porque el término es importante) el virus de la covid-19. https://t.co/cHzSNMbqzM
Fascinating to learn the mechanism of a promising #COVID19 drug, #remdesivir: https://t.co/BMTRljbyOk
here is the paper from Gilead describing how RDV-TP seems to compete with ATP for incorporation into nucleotide chain by Rd RNA polymerase causing delayed chain termination https://t.co/4iELPIkiy7
@GenomeRIK It's a weird flavor of chain terminator it seems. This paper shows that it incorporates & then the RNA terminates a few nucleotides later: https://t.co/PBfPAfXYZr Maybe RdRPs have something that clashes with the function groups on this mol
The science that comes from the #antivax lobby links quantum coherence to coherently organized biology via Remdesivir, which links naturally occurring light-actvated carbon fixation from biophysically constrained viral latency to all biodiversity on Earth.
RT @jbiolchem: How does Remdesivir inhibit #SARS-CoV-2 replication? Read more here: Paper in Press: "SARS-CoV-2 Polymerase Inhibition with…
RT @jbiolchem: How does Remdesivir inhibit #SARS-CoV-2 replication? Read more here: Paper in Press: "SARS-CoV-2 Polymerase Inhibition with…
RT @jbiolchem: How does Remdesivir inhibit #SARS-CoV-2 replication? Read more here: Paper in Press: "SARS-CoV-2 Polymerase Inhibition with…
How does Remdesivir inhibit #SARS-CoV-2 replication? Read more here: Paper in Press: "SARS-CoV-2 Polymerase Inhibition with Remdesivir" – #Enzymology #COVID19 @GileadSciences https://t.co/56NdcqWfB6 https://t.co/ZVnWV50CdD
Relevant to interpret recent significant time to recovery and mortality trend in context of basic science that suggests remdesivir works by fooling virus RNA polymerase into incorporating it instead of normal genome building blocks.. https://t.co/p53ZJx1
https://t.co/GJ5WAk6tT2 "...a direct-acting antiviral that inhibits RNA-dependent RNA polymerase..." The molecular mechanisms of its microRNA-mediated effectiveness link God's Creation of UV light & water to viral latency via the physiology of repro
@NereaIrigoyen @pflis @Nunodomin @Virolog_in Hay modelos un vitro que indican que “Incorporation of RDV-TP at position i caused termination of RNA synthesis at position i+3”. Esto implicaría que quizá ya no es accesible a la exonucleasa y se fija. 👉🏻 http
https://t.co/GJ5WAk6tT2 "Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase..." UV light-activated microRNA biogenesis links biophysically constrained viral latency across kingdoms via oxidative phosphorylation and RNA int
Remdesivir bloque cette polymerase. Plus simplement: c'est comme cette feuille qu'on insère mal dans la photocopieuse et qui bloque tout. https://t.co/HkfZBHmPtA Remdesivir a été inventé et développé par une compagnie américaine Gilead https://t.co/TM6tqI
この生化学的手法を用いた研究によれば、レムデシビルはsars-cov-2のRdRPに対して高い特異性を持っているようです。 一方、アビガンはあまり特異的ではないようです。ただ、この研究では副作用の有無についてはわかりません。https://t.co/ZTP16MVUY3, #新型コロナウィルス
If you are wondering how Remdesivir works, here is a cool paper that just came out two weeks ago! Eat it, RdRp! https://t.co/HEZ3sC1el8
The Ebola treatment remdesivir could stop #COVID19 from replicating by attacking polymerase enzymes, according to a @Ualberta study, Canada, published @jbiolchem last week https://t.co/JYbnzTxPEH Full abstract here: https://t.co/ky82nq4cb8 #DrugRepurposing
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency https://t.co/Q1RIPYIQ3P RNA依存性RNAポリメラーゼ(RdRp)の阻害が重要。
RT @organischchemie: https://t.co/ehBjzYZaQr レムデシビル(ギリアドが出したエボラ出血熱の薬)が新型コロナに効くメカニズム まさかのX-rayまで出ていて ちょっとしたSARまである 素晴らしい進捗 明日しっかり読んでみよう
RT @organischchemie: https://t.co/ehBjzYZaQr レムデシビル(ギリアドが出したエボラ出血熱の薬)が新型コロナに効くメカニズム まさかのX-rayまで出ていて ちょっとしたSARまである 素晴らしい進捗 明日しっかり読んでみよう
https://t.co/ehBjzYZaQr レムデシビル(ギリアドが出したエボラ出血熱の薬)が新型コロナに効くメカニズム まさかのX-rayまで出ていて ちょっとしたSARまである 素晴らしい進捗 明日しっかり読んでみよう
Promising study on Remdesivir "These results collectively provide a unifying, refined mechanism of RDV-mediated RNA synthesis inhibition in coronaviruses and define this nucleotide analogue as a direct-acting antiviral (DAA)." #COVID19 #hope https://t.co/
Scientists at the University of Alberta have shown that the drug remdesivir, drug originally meant for Ebola, is highly effective in stopping the replication mechanism of the coronavirus that causes COVID-19. https://t.co/nTAnONGgcy
RT @KFSHRC_Research: Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndr…
RT @KFSHRC_Research: Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndr…
RT @KFSHRC_Research: Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndr…
RT @KFSHRC_Research: Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndr…
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency https://t.co/j2udKnTFW7 https://t.co/SFbuDEwt8p
أمام هذا العمل، فقد يتكلف الأمر حوالي 10 بليون دولار الأمر الذي قد يعطل عملية إنتاج العقار بعض الوقت. المصدر: https://t.co/h4Cj7AyvlP
RT @florindanpopesq: #Remdesivir, a phosphoramidate prodrug of a cyano-substituted nucleotide analogue, is a direct-acting #antiviral that…
Some hope of remedy: https://t.co/tkWznQuYvl
RT @AgBioWorld: Remdesivir is a nucleotide analogue with broad-spectrum antiviral activity against RNA viruses including Ebola & MERS. It i…
RT @florindanpopesq: #Remdesivir, a phosphoramidate prodrug of a cyano-substituted nucleotide analogue, is a direct-acting #antiviral that…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @MeganMc76790352: @loveusaqi @kcitraro @redvetttes @ag_trader @jimcramer Correction: New information: https://t.co/gmvQI0WEcq - the risk…
RT @MeganMc76790352: @loveusaqi @kcitraro @redvetttes @ag_trader @jimcramer Correction: New information: https://t.co/gmvQI0WEcq - the risk…
@loveusaqi @kcitraro @redvetttes @ag_trader @jimcramer Correction: New information: https://t.co/gmvQI0WEcq - the risk/reward model of the remdesivir drug that I commented on before has been addressed here. This recent paper suggests remdesivir directly te
RT @AgBioWorld: Remdesivir is a nucleotide analogue with broad-spectrum antiviral activity against RNA viruses including Ebola & MERS. It i…
RT @DrFALOTAIBI: وفقًا لدراسة جديدة نُشرت في مجلة الكيمياء البيولوجية ، فإن ريمديسيفير ، وهو دواء مضاد للفيروسات ، يهاجم الفيروس التاجي. و…
RT @florindanpopesq: #Remdesivir, a phosphoramidate prodrug of a cyano-substituted nucleotide analogue, is a direct-acting #antiviral that…
#Remdesivir, a phosphoramidate prodrug of a cyano-substituted nucleotide analogue, is a direct-acting #antiviral that inhibits RNA-dependent RNA polymerase #RdRp from SARS-CoV-2 with high potency. Its triphosphate form resembles ATP [Gordon CJ et al. 2020]
RT @DrFALOTAIBI: وفقًا لدراسة جديدة نُشرت في مجلة الكيمياء البيولوجية ، فإن ريمديسيفير ، وهو دواء مضاد للفيروسات ، يهاجم الفيروس التاجي. و…
RT @Barton_options: This recent paper suggests remdesivir directly terminates RNA replication for COVID19, so ignore the speculation that I…
RT @Barton_options: This recent paper suggests remdesivir directly terminates RNA replication for COVID19, so ignore the speculation that I…
وفقًا لدراسة جديدة نُشرت في مجلة الكيمياء البيولوجية ، فإن ريمديسيفير ، وهو دواء مضاد للفيروسات ، يهاجم الفيروس التاجي. وقد تعافى المرضى (Covid-19) بسرعة بعد الحصول على عقار ريمديسفير التجريبي. https://t.co/5VhjJaAQS4
@Ubiquitin13 @cetintuker @halukpeksen @SelcukRSirin Olağanüstü durum olması preprint koyamayacağı anlamına mı geliyor ? Hadi dergide basılması 1-2 ayı buldu, biorxive koyun. Bakın her gün 2-3 bin insanı ölen Amerikada kimse Twitter'da açıkama yapmıyor. htt
RT @ISARICAR: Efficient incorporation and termination of #SARSCoV2 RdRp-catalyzed RNA synthesis by Remdesivir-triphosphate #antivirals htt…
RT @Barton_options: This recent paper suggests remdesivir directly terminates RNA replication for COVID19, so ignore the speculation that I…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @Barton_options: This recent paper suggests remdesivir directly terminates RNA replication for COVID19, so ignore the speculation that I…
This recent paper suggests remdesivir directly terminates RNA replication for COVID19, so ignore the speculation that I outlined above H/t @lumosbio https://t.co/zgZU6a4aez
RT @AgBioWorld: Remdesivir is a nucleotide analogue with broad-spectrum antiviral activity against RNA viruses including Ebola & MERS. It i…
Bring it on💪
RT @AgBioWorld: Remdesivir is a nucleotide analogue with broad-spectrum antiviral activity against RNA viruses including Ebola & MERS. It i…
Remdesivir is a nucleotide analogue with broad-spectrum antiviral activity against RNA viruses including Ebola & MERS. It inhibits the replication by the virus by inhibiting RNA-dependent RNA polymerase https://t.co/1wKqA6HgVs
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. https://t.co/MAd1hvtIWI
RT @JulienSourimant: Nice in vitro study of Remdesivir and SARS-CoV-2 from Götte's lab! https://t.co/inia4OAGxW
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. Gordon, Calvin J. et al. (2020). Journal of Biological Chemistry https://t.co/xiqgciaerf
RT @FakeStateRF: 🇺🇳🇨🇦Канадские вирусологи подтвердили эффективность препарата ремдесивир в борьбе с коронавирусом. Соответствующее исследов…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @KFSHRC_Research: Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndr…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
RT @jbiolchem: Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of S…
Researchers from @UAlberta have shown that Remdesivir, a drug originally developed to treat Ebola, inhibits replication of SARS-CoV-2 and shows promise as a broad spectrum pharmaceutical treatment for coronaviruses. – #COVID19 #Enzymology #coronavirus htt
RT @ISARICAR: Efficient incorporation and termination of #SARSCoV2 RdRp-catalyzed RNA synthesis by Remdesivir-triphosphate #antivirals htt…
RT @ISARICAR: Efficient incorporation and termination of #SARSCoV2 RdRp-catalyzed RNA synthesis by Remdesivir-triphosphate #antivirals htt…
Efficient incorporation and termination of #SARSCoV2 RdRp-catalyzed RNA synthesis by Remdesivir-triphosphate #antivirals https://t.co/eP3JS2yjx1
RT @KFSHRC_Research: Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndr…